Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 23062-51-3, name is Methyl 4-bromobicyclo[2.2.2]octane-1-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 4-bromobicyclo[2.2.2]octane-1-carboxylate
To the title compound from the Preparative Example 55, Step A (677 mg) was added 10% aqueous NaOH (65 niL). The mixture was stirred at 100C (temperature of the oil bath) for 42 h, concentrated to 15 mL and diluted with IN aqueous HCl (3O mL). The resulting mixture was acidified to pH 1 with 12N aqueous HCl and extracted with EtOAc (5 x 70 mL). The combined organic phases were dried (MgSO4), filtered and concentrated to afford the title compound (540 mg, 89%). [MH]+ = 171
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ALANTOS-PHARMACEUTICALS, INC.; WO2006/128184; (2006); A2;,
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