These common heterocyclic compound, 99548-55-7, name is Methyl 4-bromo-2-methylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 99548-55-7
Example 17: 4-cyano-2-methylbenzoic acid methyl ester; To a solution of 4-bromo-2-methylbenzoic acid (108 g, 471 mmol) inLambda/,Lambda/-dimethylformamide (4 L) under a nitrogen atmosphere was added zinc (II) cyanide (88.5 g, 753.6 mmol) and tetrakis(triphenylphosphine)palladium (65 g, 56.60 mmol). The reaction mixture was stirred at 1000C for 16 hours. The reaction mixture was diluted with toluene and the phases were separated. The aqueous phase was extracted twice with toluene. The combined organic phases were washed with brine and saturated aqueous ammonium hydroxide, dried over sodium sulfate and concentrated. The residue was purified by column chromatography on silica gel (eluent: ethyl acetate / cyclohexane 1 :5) to give 4-cyano-2- methylbenzoic acid methyl ester (73 g, 89percent yield). 1H NMR (400 MHz, CDCl3): 7.78 (d, IH), 7.52 (m, 2H), 3.92 (s, 3H), 2.62 (s, 3H) ppm.
The synthetic route of Methyl 4-bromo-2-methylbenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; MAIENFISCH, Peter; GODFREY, Christopher Richard Ayles; JUNG, Pierre Joseph Marcel; HUETER, Ottmar Franz; RENOLD, Peter; WO2010/127928; (2010); A1;,
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