Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C9H11NO3
A solution of 1-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}methyl)-5-methyl-1 H-pyrazole-3- carboxylic acid (807 mg), methyl 4-amino-2-methoxybenzoate (453 mg), N-(3- dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (516 mg) and 1- hydroxybenzotriazole hydrate (406 mg) in dichloromethane (10 ml) and dimethylformamide (10 ml) was stirred at ambient temperature for 24 hours. Ethyl acetate (60 ml) was added and the mixture washed with water (60 ml), saturated sodium bicarbonate solution (25 ml) and brine (2 x 20 ml), dried (MgSO4) and concentrated in vacuo. The residue was purified by SP4 Biotage chromatography using 5 to 40percent ethyl acetate in hexane to afford the title compound (738 mg, 61percent) as a white foamy solid. LC/MS [MH+] = 486/488, RT = 3.70 min.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 27492-84-8.
Reference:
Patent; GLAXO GROUP LIMITED; WO2006/114313; (2006); A1;,
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