Electric Literature of 6091-64-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6091-64-1, name is Ethyl 2-bromobenzoate, This compound has unique chemical properties. The synthetic route is as follows.
Example 4 To a solution (25 ml) of 2-(4-trifluoromethylphenyl)furan (3.18 g) in tetrahydrofuran was added dropwise n-butyl lithium (1.6 M solution in hexane, 10.0 ml) under an argon atmosphere at -78C. This mixed solution was heated to room temperature, and a solution (30 ml) of zinc chloride (2.25 g) in tetrahydrofuran was added. This mixture was stirred for 1 hr., and then ethyl 2-bromobenzoate (2.38 ml) and tetrakis (triphenylphosphine)palladium (0.433 g) were added. This mixture was stirred overnight under an argon atmosphere, and then poured into 0.5 M hydrochloric acid. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution and saturated brine, dried over anhydrous magnesium sulfate and concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=10:1, volume ratio) to give ethyl 2-[5-(4-trifluoromethylphenyl)-2-furyl]benzoate (2.54 g, yield 47%) as a pale-yellow oil. NMR (CDCl3) delta: 1.12 (3H, t, J = 7.2 Hz), 4.27 (2H, q, J = 7.2 Hz), 6.70 (1H, d, J = 3.6 Hz), 6.87 (1H, d, J = 3.6 Hz), 7.41 (1H, dt, J = 1.4, 7.4 Hz), 7.53 (1H, dt, J = 1.4, 7.4 Hz), 7.61-7.79 (6H, m).
The chemical industry reduces the impact on the environment during synthesis Ethyl 2-bromobenzoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1405636; (2004); A1;,
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