Application of 42122-75-8,Some common heterocyclic compound, 42122-75-8, name is Methyl 5-amino-2-chlorobenzoate, molecular formula is C8H8ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1.1 2-Chloro-5-phenylamino-benzoic acid methyl ester Cs2CO3 (2.79 g), palladium(II) acetate (82 mg), 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene (228 mg), iodobenzene (0.69 mL) and methyl-5-amino-2-chlorobenzoate (1.13 g) were placed in a flask and flushed with argon. Dioxane (18 mL) was added and the reaction mixture was heated to 100 C. for 24 h. After cooling to RT, it was diluted with Et2O, filtered over a pad of celite and the filtrate was concentrated in vacuo. The crude material was purified by CC (Hept/EtOAc 1/0 to 8/2) to give 1.18 g of the titled compound as a light yellow solid. LC-MS (A): tR=1.05 min; [M+H]+: 262.55.
The synthetic route of 42122-75-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Actelion Pharmaceuticals Ltd.; Hilpert, Kurt; Hubler, Francis; Murphy, Mark; Renneberg, Dorte; US2014/73651; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics