Synthetic Route of 10602-06-9, A common heterocyclic compound, 10602-06-9, name is Methyl 3-ethynylbenzoate, molecular formula is C10H8O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A. Under the conditions of example 5A, 9.2 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 4.8 g of 3-ethinylbenzoic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with hexane/0-20% ethyl acetate. 4.7 g of 3-{3-hydroxy-6-[2-(3-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester of melting point 125-127 C. is obtained. IR(CHCl3): 3250 (broad), 2950, 1718, 1453, 1435, 1258, 1098, 1010 cm-1.
The synthetic route of 10602-06-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Schering Aktiengesellschaft; US5624943; (1997); A;,
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