In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59247-47-1 as follows. Product Details of 59247-47-1
To a solution of tert-butyl 4-bromobenzoate (2 g, 7.8 mmol) and 4,4,4?,4?,5,5,5?,5?-octamethyl-2,2?-bi(1,3,2-dioxaborolane) (4 g, 16 mmol) in 1,4-dioxane (30 mL) was added 1,1?-bis(diphenylphosphino)ferrocene-palladium(II) dichloride dichloromethane (0.64 g, 0.8 mmol) and potassium acetate (3.0 g, 31 mmol). The reaction mixture was stirred at 90¡ã C. under nitrogen for 12 hours. After the reaction, it was allowed to cool to room temperature and concentrated in vacuo, then diluted with ethyl acetate (100 mL), washed with water (100 mL). The organic phase was dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated and the residue was purified by column chromatography (silica gel, ethyl acetate/petroleum ether=1:20) to give the pure product tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (1.8 g, 75percent). 1H NMR (300 MHz, CDCl3): delta 7.95 (d, J=8.1 Hz, 2H), 7.83 (d, J=8.4 Hz, 2H), 1.59 (s, 9H), 1.35 (s, 12H).
According to the analysis of related databases, 59247-47-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Constellation Pharmaceuticals, Inc.; Albrecht, Brian K.; Audia, James Edmund; Cook, Andrew S.; Gagnon, Alexandre; Harmange, Jean-Christophe; Nasveschuk, Christopher G.; US9206128; (2015); B2;,
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