Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 454-31-9, name is Ethyl 2,2-difluoroacetate, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H6F2O2
Intermediate 15 (2.57 g, 0.0101 mol) was stirred in toluene (150 mL) at 0C under N2. Potasssium tert.-butoxide (1.59 g, 14.2 mmol) was added at 0-5C, ethyldifluoroacetate (1.52 g, 0.0122 mol) was added dropwise at 0-5C. RM was stirred at RT for 2 h. The RM was washed with 10%> H2SO4 in water and the OL was dried on MgS04, filtered and evaporated to yield intermediate 16 (3.34 g, 99%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; VAN ROOSBROECK, Yves, Emiel, Maria; BUIJNSTERS, Peter, Jacobus, Johannes, Antonius; TRESADERN, Gary; JACOBY, Edgar; OEHLRICH, Daniel; GIJSEN, Henricus, Jacobus, Maria; (67 pag.)WO2018/83103; (2018); A1;,
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