Related Products of 41658-03-1, These common heterocyclic compound, 41658-03-1, name is Ethyl 3-bromopropiolate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A dry and argon flushed Schlenk-flask, equipped with a magnetic stirring bar and a rubber septumwas charged with 1,8-bis(butylthio)-3,6-dichloro-2,7-naphthyridine (1.0 equiv) in THF. After cooling to-40 C, a solution of TMPLi (1 M in THF, 1.2 equiv) was slowly added. The reaction mixture wasstirred for 30 min at the same temperature. Then, the corresponding electrophile (1.2 equiv) wasadded and the solution was stirred at -40 C until complete conversion of the starting material(detected by GC-analysis of reaction aliquots).
The synthetic route of 41658-03-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Greiner, Robert; Blanc, Romain; Petermayer, Christian; Karaghiosoff, Konstantin; Knochel, Paul; Synlett; vol. 27; 2; (2016); p. 231 – 236;,
Ester – Wikipedia,
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