Adding a certain compound to certain chemical reactions, such as: 6914-71-2, name is 1,1-Cyclopropanedicarboxylic acid dimethyl ester, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6914-71-2, Application In Synthesis of 1,1-Cyclopropanedicarboxylic acid dimethyl ester
Synthesis of Cyclopropane-1,1-dicarboxylic acid methyl ester KOH (42 mg, 0.75 mmol) was added to a solution cyclopropane-1,1-dicarboxylic acid dimethyl ester (100 mg, 0.63 mmol) in methanol. The resulting mixture was stirred for 4 hours at ambient temperature then concentrated. The residue was diluted with water, acidified with conc. HCl and the product was extracted with dichloromethane. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford 65 mg (71%) of cyclopropane-1,1-dicarboxylic acid methyl ester.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,1-Cyclopropanedicarboxylic acid dimethyl ester, and friends who are interested can also refer to it.
Reference:
Patent; FOREST LABORATORIES HOLDINGS LIMITED; US2009/239848; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics