Continuously updated synthesis method about 5326-50-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(1-hydroxycyclohexyl)acetate, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 5326-50-1, name is Ethyl 2-(1-hydroxycyclohexyl)acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5326-50-1, name: Ethyl 2-(1-hydroxycyclohexyl)acetate

To a solution of X4 (510 mg) in MeOH was added IN aqueous NaOH. The reaction mixture was stirred at 600C for Ih5 and then concentrated in vacuo. The residue was diluted with water, washed with Et2O and the aqueous layer acidified with IN aqueous citric acid and extracted with EtOAc. The organics were dried (MgSO4) and concentrated in vacuo to yield after recrystallization compound X5 (220mg): 1H-NMR (CDCl3, 500MHz) 3.63 (s, IH), 2.45 (s, 2H), 1.22-1.64 (m, 10H) ppm; FIA m/z 157.2 ES”.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(1-hydroxycyclohexyl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2007/25307; (2007); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics