Application of 58656-98-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 58656-98-7, name is tert-Butyl 4-fluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Preparation of 4-[4-(2-Aminoethyl phenoxy]benzoic acid, tert-butyl ester Tyramine (700 mg, 5.1 mmol) was added to a magnetically stirred suspension of potassium hydride (35 wt. percent dispersion in oil; 876 mg, 7.64 mmol) in DMF (20 mL) at 25 C. After effervescence stopped, tert-butyl 4-fluorobenzoate (1.0 g, 5.1 mmol) was added. After stirring at 25 C. for 64 hours, the reaction was warmed to 60 C. After 48 h, the reaction was poured into brine and extracted with hexanes (3*25 mL) and ethyl acetate (2*25 mL). Organic layers washed separately with aqueous 2 N NaOH, dried (Na2SO4), then pooled, evaporated and purified by silica gel chromatography (CH2Cl2:MeOH/2:1) to provide 0.98 g of clear oil.
The synthetic route of tert-Butyl 4-fluorobenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Brewster, William Kirkland; Demeter, David Anthony; Erickson, William Randal; Klittich, Carla Jean Rasmussen; Lowe, Christian Thomas; Rieder, Brent Jeffrey; Nugent, Jaime Susanne; Yerkes, Carla Nanette; Zhu, Yuanming; Balko, Terry William; US2007/93498; (2007); A1;,
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