Related Products of 706791-83-5,Some common heterocyclic compound, 706791-83-5, name is Methyl 3-amino-5-bromobenzoate, molecular formula is C8H8BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 7 mL vial was added a carboxylic acid compound (332 mg, 1.2 mmol), methyl 3-amino-5-bromobenzoate (270 mg, 1.2 eq)EDCI (3.0 eq), HOBt (3.0 eq) and DIPEA (3.0 eq) were dissolved in DMF (0.3 M) and stirred at room temperature for 16 hRespectively. After completion of the reaction, the mixture was extracted three times with a mixed solvent of H2O / EA, and the organic layer was washed with saturated sodium carbonate. The organic layerAfter drying with MgSO4, the solvent was concentrated under reduced pressure, and a silica gel column was carried out to obtain the title compound (475 mg, 83%)
The synthetic route of 706791-83-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; YONSEI University Office of Research Affairs / University Industry Foundation; Korea Research Institute of Chemical Technology; Jang Seong-yeon; Lee Hyeok; Kim Seong-hwan; Kim Beom-tae; Kim Seong-su; Huh Jeong-nyeong; Im Hwan-jeong; Im Seung-gil; Kang Myeong-mo; Noh Gyeong-tae; Lee Gyeong-ro; Choi Ji-won; (147 pag.)KR2017/94087; (2017); A;,
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