Reference of 23426-63-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 23426-63-3, name is Methyl 2-bromo-2-methylpropanoate, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 3-PYRIDIN-3-YL-PHENOL (0.86 g, 5.0 mmol), methyl 2- bromoisobutyrate (3.60 g, 20.0 MMOL), and K2CO3 (2.76 g, 20.0 mmol) in anhydrous DMF (10 mL) was heated at 93 C under nitrogen for 3 h. After cooling, brine (40 mL) was added and the mixture was extracted with ethyl acetate (50 mL). The separated organic layer was washed with brine, filtered, and concentrated. The oil residue was taken up in 10 mL of 3 M HCI, stirred for 10 min, diluted with brine (10 mL), and extracted with ethyl acetate (2 x 30 mL). The separated aqueous layer was cooled in ice/water bath, adjusted to pH 10 with solid NA2CO3, and extracted with ethyl acetate (2 x 40 mL). The organic extract was dried over sodium sulfate and concentrated to afford 1.09 g (80%) of 2-METHYL-2- (3-PYRIDIN-3-YL-PHENOXY)-PROPIONIC acid methyl ester as a yellow oil :’H NMR (CD3) 6 1.62 (s, 6H), 3.79 (s, 3H), 6.82 (dd, 1 H), 7.08 (s, 1 H), 7.20 (d, 1 H), 7.38 (m, 2H), 7.81 (d, 1 H), 8.59 (d, 1 H), 8.80 (s, 1 H) ; MS M/Z (relative intensity) 271 (M+, 20), 212 (30), 171 (100).
The chemical industry reduces the impact on the environment during synthesis Methyl 2-bromo-2-methylpropanoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/48334; (2004); A1;,
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