Application of 426-65-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 426-65-3, name is Ethyl Pentafluoropropionate, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a solution of alkyne (1.0 eq) in THF (0.5 M) was added dropwise n-BuLi in solution in hexanes (1.1 eq) at -78 C. The mixture was stirred for 1 h at -78 C and ethyl trifluoroacetate (1.5 eq) was added. After the complete consumption of the alkyne (TLC), the mixture was diluted with MeOH (same volume than THF). The mixture was allowed to warm up to 0 C and NaBH4 (1.0 eq) was added. The mixture was stirred overnight while warming up to room temperature. The reaction was then quenched with a saturated solution of NH4Cl, extracted with Et2O (x3), washed with water and brine, dried over MgSO4 and concentrated under reduced pressure to give the alpha-trifluoromethyl secondary propargylic alcohol. The crude product was purified by flash column chromatography to afford the pure product.
The chemical industry reduces the impact on the environment during synthesis Ethyl Pentafluoropropionate. I believe this compound will play a more active role in future production and life.
Reference:
Article; Boreux, Arnaud; Lambion, Aubin; Campeau, Dominic; Sanita, Marina; Coronel, Ruben; Riant, Olivier; Gagosz, Fabien; Tetrahedron; vol. 74; 38; (2018); p. 5232 – 5239;,
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