A new synthetic route of 39149-80-9

According to the analysis of related databases, 39149-80-9, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39149-80-9, name is tert-Butyl 2-bromopropanoate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H13BrO2

A.i. (RS)-tert-Butyl 2-(methylsulfonyl)propanoate : To a suspension of sodium methanesulfinate (100 g; 929 mmol) in tBuOH (350 mL) was added iert-butyl-2-bromopropionate (150 mL; 877 mmol). The reaction mixture was stirred at 90C for 24 h under nitrogen atmosphere, then cooled to rt and concentrated to dryness. The residue was partitioned between water (750 mL) and EA (600 mL). The aq. layer was extracted with EA (2 x 500 mL). The evaporation residue afforded the title compound as a white yellow solid (175 g; 96% yield). 1H NMR (DMSO-d6) delta: 4.24 (q, J = 7.2 Hz, 1H); 3.1 1 (s, 3H); 1.45 (s, 9H); 1.40 (d, J = 7.2 Hz, 3H).

According to the analysis of related databases, 39149-80-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; DIETHELM, Stefan; GAUVIN, Jean-Christophe; JACOB, Loic; PANCHAUD, Philippe; SCHMITT, Christine; SURIVET, Jean-Philippe; TIDTEN-LUKSCH, Naomi; (79 pag.)WO2019/86452; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics