These common heterocyclic compound, 85953-29-3, name is Methyl 2-chloro-4-fluorobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 85953-29-3
2-Chloro-4-fluoro-benzoic acid methyl ester (500 mg, 2.65 mmol) and 4-bromophenol (504 mg, 2.9131 mmol) were sequentially added to the dry reaction flask.Potassium carbonate (731 mg, 5.2971 mmol), DMAc (5 mL), protected by a nitrogen balloonThe reaction was heated to 120 C for 12 h, cooled to rt then water (20 mL) and ethyl acetate (20 mL). The aqueous phase was added with 1 M hydrochloric acid, and the pH was adjusted to 3-4, then ethyl acetate (15 mL) was added to precipitate a white solid and filtered.The filter cake was washed with ethyl acetate (5 mL).The title compound is a white solid(230 mg, 27%).
The synthetic route of Methyl 2-chloro-4-fluorobenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Liu Xinchang; Huang Jianzhou; Zhang Yingjun; S ¡¤geerdeman; (267 pag.)CN109111451; (2019); A;,
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