Adding a certain compound to certain chemical reactions, such as: 541-16-2, name is Di-tert-Butyl malonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 541-16-2, Quality Control of Di-tert-Butyl malonate
To a 100 mL round bottom flask, was added p-acetamidobenzenesulfonyl azide (1.08 g, 4.5 mmol), acetonitrile (25 mL), triethylamine (0.62 mL, 4.5 mmol), and di-tert-butyl malonate (1 mL, 4.5 mmol). The reaction was stirred at rt for 48 hours, after which time the mixture was concentrated in vacuo to near dryness. Hexanes (25 mL) was added to the crude material and the precipitate was filtered. The filtrate was concentrated in vacuo and used directly in the following procedure. To a 100 mL round bottom flask containing the above crude material (1.87 g, 7.7 mmol), was added Rh2(OAc)4 (35 mg, 0.08 mmol) and toluene (50 mL), and 2-hydroxyEtOAc (1.24 g, 11.55 mmol). 1 The reaction was stirred at 70 C overnight, after which time the mixture was filtered over Celite and purified by silica gel column chromatography (20% EtOAc/hexanes) to afford the intermediate as a colorless oil (936 mg, 33% yield) which was used directly in the next step.
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Reference:
Article; Kelley, Amber M.; Minerali, Eni; Wilent, Jennifer E.; Chambers, Nicholas J.; Stingley, Kyla J.; Wilson, G. Tyler; Petersen, Kimberly S.; Tetrahedron Letters; (2019);,
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