Reference of 18595-18-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18595-18-1, name is Methyl 3-amino-4-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Ammonium thiocyanate (50 mmol) is dissolved in 50 ml of acetone, 40 C lower dropwise acetyl chloride (50 mmol) in 10 ml acetone solution, stirring 1 hour, then cooling to room temperature, is slowly added 3-amino-4-methyl benzoic acid methyl ester in 75 ml of acetone solution, stirring the mixture at room temperature for 5 hours, adding 100 ml of water, is continuously stirred for 1 hour, filtering the precipitation separated out, water washing 3 times, hexane washing 3 times, vacuum drying to obtain title compound 11.3 g. 1 H-NMR (DMSO), delta 12.19 (1H, s), 11.56 (1H, s), 8.18 (1H, s), 7.77 (1H, d, J=8.0Hz), 7.45 (1H, d, J=8.0Hz), 3.84 (3H, s), 2.27 (3H, s), 2.17 (3H, s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-amino-4-methylbenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CHIA TAI TIANQING PHARMACEUTICALGROUP CO LTD; Beijing Centaurus Biopharma Technology?Co.,?Ltd.; XIAO, DENGMING; LIANG, ZHI; HU, YUANDONG; HU, QUAN; ZHANG, QINGHUI; HAN, YONGXIN; WANG, HUAN; PENG, YONG; KONG, FANSHENG; LUO, HONG; (60 pag.)CN103130792; (2016); B;,
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