Adding a certain compound to certain chemical reactions, such as: 90971-88-3, name is Methyl 2-bromo-5-methylbenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 90971-88-3, Quality Control of Methyl 2-bromo-5-methylbenzoate
To a mixture of 5-amino-3-ethyl-1-(2-methoxy-phenyl)-1 H-pyrazole-4-carbonitrile (Example 99, 1.0 g, 4.11 mmol), 2-bromo-5-methyl-benzoic acid methyl ester (0.78 g, 3.43 mmol) in toluene (25 mL) was added BINAP (0.21 g, 0.34 mmol) followed by tris (dibenzylideneacetone) (0) (0.19 g, 0.21 mmol). To the mixture was added cesium carbonate (1.56 g, 4.80 mmol) and the suspension was heated at 118C overnight and cooled to rt. Then reaction mixture was diluted with ethyl acetate and filtered through Celite and concentrated. The residue purified by silica gel column chromatography (25% ethyl acetate-hexanes) to give a pale yellow foamy solid (1.22 g, 91%). ES-MS m/z391.1 (MH+); HPLC RT (min) 3.73.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromo-5-methylbenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2005/112923; (2005); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics