Electric Literature of 13195-64-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13195-64-7, name is Diisopropyl malonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: The catalyst 10a/10b (0.01 mmol) and aldehyde 1(0.1 mmol) were dissolved in ethanol (2.0 mL). The reactionmixture was stirred for about 10 min, and then malonate2 (1.0 mmol) and triethylamine (0.2 mmol) were added atroom temperature. After vigorous stirring for about 48-72 h,the reaction mixture was poured into water (3 mL) andextracted with ethyl acetate (3 ¡Á 15 mL). The organic fractionwas dried over anhydrous MgSO4and concentratedunder reduced pressure. The crude product was purified bycolumn chromatography to afford 3a-p as desired products.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diisopropyl malonate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ashokkumar, Veeramanoharan; Siva, Ayyanar; Sankar, Balakrishnan; Journal of the Iranian Chemical Society; vol. 16; 9; (2019); p. 1939 – 1955;,
Ester – Wikipedia,
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