Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 57381-43-8, name is Methyl 2,5-dibromobenzoate, A new synthetic method of this compound is introduced below., COA of Formula: C8H6Br2O2
To a dried 25 mL flask was introduced 3-tert-butyl-1-(2-methylphenyl)-1 H-pyrazol-5-amine (220 mg, 0.96 mmol), methyl 2,5-dibromobenzoate (235 mg, 0.80 mmol), Pd2(dba)3 (36.6 mg, 0.04 mmol), BINAP (49.8 mg, 0.08 mmol), and Cs2CO3 (365 mg, 1.12 mmol). The flask was degassed followed by addition of toluene (1 mL), and the mixture was then heated to 110¡ãC for 20 h. The mixture was cooled to rt, and diluted with ethyl acetate. The solid was filtered off, and the solvent was removed under reduced pressure. The residue was redissolved in methanol/THF (4: 1, v/v) and filtered though a C8-silica plug. HPLC purification using a gradient elution from 10percent to 90percent acetonitrile in water afforded 110 mg (31 percent) of the title compound. 1H NMR (300 MHz, CD2Cl2) No. 9.21 (s, 1 H), 7.41 (d, 1 H), 7.20-7.30 (m, 5 H), 7.10 (d, 1 H), 6.09 (s, 1 H), 3.72 (s, 3 H), 2.04 (s, 3 H), 1.30 (s, 9 H). ES-MS m/z 444.1 (MH+); HPLC RT (min) 4.30.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2005/112923; (2005); A2;,
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