Synthetic Route of 122-72-5,Some common heterocyclic compound, 122-72-5, name is 3-Phenylpropyl Acetate, molecular formula is C11H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: In a typical example, a substituted benzene (1.0mmol), as shown in Table 6, was treated with H2 (30atm) with stirring at 30 or 50C in the presence of Ru-1 (Ru=0.003mmol, S/C=333, in 1mL of H2O) in an autoclave with an inner glass tube. The product was extracted with EtOAc (3mL¡Á5) and the combined extracts were dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified using a short silica gel column. The hydrogenation of anisole on a large scale [toluene=24mmol (S/C=1400)] is described in the Supplementary data.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Phenylpropyl Acetate, its application will become more common.
Reference:
Article; Gao, Lei; Kojima, Keisuke; Nagashima, Hideo; Tetrahedron; vol. 71; 37; (2015); p. 6414 – 6423;,
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