Reference of 73792-08-2,Some common heterocyclic compound, 73792-08-2, name is Methyl 4-amino-2-fluorobenzoate, molecular formula is C8H8FNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[00471] Under an atmosphere of argon acetyl chloride (2.0 mL, 31 mmol) in dichloromethane (5 mL) was added dropwise to a stirred solution of 59 (2.0 g, 12 mmol) and Hunig’s base (8 mL, 48 mmol)) in dichloromethane (50 mL) at -10 C. The reaction was stirred for 1 hour then quenched with saturated sodium bicarbonate solution (50 mL). The mixture was extracted with dichloromethane (3 x 30 mL) and combined extracts dried with sodium sulfate. The mixture was concentrated under reduced pressure. Flash chromatography (ISCO system, silica, 0-100% ethyl acetate in hexane) provided 60 (2.07 g, 83%) as a solid: LRESIMS m/z 212.0 [M+H]+, calcd. for C10H11F1N1O3 212.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 4-amino-2-fluorobenzoate, its application will become more common.
Reference:
Patent; CALCIMEDICA, INC.; ROGERS, Evan; CAO, Jianguo; WANG, Zhijun; GREY, Jonathan; WHITTEN, Jeffrey, P.; WO2014/43715; (2014); A1;,
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