In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 193290-19-6 as follows. name: Methyl 2-(4-bromo-2-fluorophenyl)acetate
To a solution of methyl 2-(4-bromo-2-fluorophenyl) acetate (1 g, 4.05 mmol) in toluene/THF H20 (15 mL, v/v/v=2/2/l ) were added 2-methylpyridin-3-ylboronic acid (870 mg, 3.97 mmol), AcO (790 mg, 8.05 mmol) and PdCl2(dppf) (222 mg, 0.31 mmol) under nitrogen. The reaction mixture was stirred at 90C for 15 h. The reaction mixture was filtered, the filtrate was washed with water, extracted with EtOAc (2 x 10 mL). The combined layers were washed with brine, dried over Na2S04 and concentrated. The residue was purified by column chromatography on silica gel eluted with 0- 10% EtOAc in petroleum ether to afford the desired product (0.9 , 86%). LCMS m/z 260 (M+l )+.
According to the analysis of related databases, 193290-19-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AFRAXIS, INC.; CAMPBELL, David; DURON, Sergio, G.; WO2013/43232; (2013); A2;,
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