Reference of 496841-90-8,Some common heterocyclic compound, 496841-90-8, name is Ethyl 2-fluoro-5-methylbenzoate, molecular formula is C10H11FO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 11-2 Ethyl 5-(bromomethyl)-2-fluorobenzoate To a solution of ethyl 2-fluoro-5-methylbenzoate (243 mg) in carbon tetrachloride (6.7 mL), N-bromosuccinimide (261 mg) and 2,2′-azobis(isobutyronitrile) (22 mg) were added, and the mixture was stirred at an outer temperature of 65C for 2 hours. After the reaction solution was concentrated under reduced pressure, the obtained residue was purified by silica gel column chromatography (n-hexane:ethyl acetate = 49:1 to 17:3) to give the title compound (208 mg) as a colorless oil. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.36 – 1.46 (m, 3 H) 4.34 – 4.45 (m, 2 H) 4.48 (s, 2 H) 7.07 – 7.16 (m, 1 H) 7.48 – 7.58 (m, 1 H) 7.92 – 7.98 (m, 1 H). MS ESI/APCI Multi posi: 283[M+Na]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2-fluoro-5-methylbenzoate, its application will become more common.
Reference:
Patent; Taisho Pharmaceutical Co., Ltd.; TANAKA, Hiroaki; KAWAMURA, Madoka; HAMADA, Makoto; KOBASHI, Yohei; ITO, Yuji; SUZUKI, Kazuaki; BOHNO, Ayako; FUNAYAMA, Kosuke; (510 pag.)EP3666766; (2020); A1;,
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