Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5335-05-7, name is Chloromethyl benzoate, A new synthetic method of this compound is introduced below., Safety of Chloromethyl benzoate
b) Compound B59:To a solution of Compound B29 (1.06g, 3.19 mmol; Example 11 (c)) and silver carbonate (0.86 g, 3.19 mmol) in acetonitrile (25 mL) was added chloromethylbenzoate (2.73 mL, 16.0 mmol). The mixture was stirred for 4h at 600C and filtered over a pad of Celite. The cake was washed with acetonitrile (2x20ml). The filtrate was concentrated in vacuo and the residue was purified by silica gel chromatography (hexanes/ethyl acetate 90:10 to 50:50). Compound B59 (1.30 g, 97% yield) was obtained as a colorless oil. 1H NMR (CDCI3, 500 MHz) delta in ppm 1.24 (s, 6H), 1.26 (t, J=7.0Hz, 3H), 2.39 (quint, J=7.5Hz, 2H), 3.30 (t, J=7.0Hz, 2H), 3.44 (t, J=7.5Hz, 2H), 4.15 (q, J=7.5Hz, 2H), 4.19 (s, 2H), 6.07 (s, 2H), 7.50 (t, J=7.5Hz, 2H), 7.65 (t, J=7.5Hz, 1 H), 8.09 (d, J=7.0Hz, 2H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BELLUS HEALTH (INTERNATIONAL) LIMITED; KONG, Xianqi; LEVENS, Nigel; BOUZIDE, Abderrahim; CIBLAT, Stephane; FRENETTE, Richard; RENAUD, Johanne; WO2011/17800; (2011); A1;,
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