Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 64123-77-9, name is Methyl 2-(3-fluorophenyl)acetate, A new synthetic method of this compound is introduced below., Quality Control of Methyl 2-(3-fluorophenyl)acetate
Intermediate 99: Methyl 2-chlorosulfonyl-5-fluorophenylacetate Methyl 3-fluorophenylacetate (1.51g) was added dropwise to chlorosulphonic acid (7mL) with stirring and ice cooling. The cooling bath was removed and the mixture was allowed to warm to room temperature and left to stand for 16 hours. The mixture was added toa mixture of ice and ethyl acetate and the organic layer was separated, washed with water, dried (MgSO4) and filtered. The filtrate was concentrated in vacuo and the residue was purified by chromatography on silica, eluting with a mixture of ethyl acetate and cyclohexane, with a gradient of 0-20%, to give methyl 2-chlorosulfonyl-5-fluorophenylacetate (1.42g) as a white solid.j00636j ?HNMR(CDC13) : 8.16 (1H, dd), 7.29-7.16 (2H, m), 4.19 (2H, s), 3.76 (3H, s).
The synthetic route of 64123-77-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZAFGEN, INC.; PALLIN, Thomas, David; CRAMP, Susan, Mary; DYKE, Hazel, Joan; ZAHLER, Robert; WO2014/71369; (2014); A1;,
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