These common heterocyclic compound, 29547-04-4, name is Methyl 2,4-dibromobutanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Methyl 2,4-dibromobutanoate
A solution of N;,N2-dibenzylethane- 1 ,2-diamine (1.0 eq), methyl 2,4-dibromobutanoate (1.1.0 eq) and Et3N (3.0 eq) in DCM (0.77 M) was stirred in a sealed tube at 60 C fo 16 h. The mixture was diluted with DCM, washed with sat. aq. NaHC03, brine, dried and concentrated. The residue was purified by flash chromatography (petroleum ether/EtOAc from 90: 10 to 0: 100) to give the title compound (57%) as an oil. MS (ES+) m/z 339 (M+H)+.
The synthetic route of Methyl 2,4-dibromobutanoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IRBM SCIENCE PARK S.P.A.; C.N.C.C.S. S.C.A.R.L. COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING; BIANCOFIORE, Ilaria; CIAMMAICHELLA, Alina; FERRIGNO, Federica; HARPER, Steven; MALANCONA, Savina; ONTORIA ONTORIA, Jesus Maria; PAONESSA, Giacomo; PONZI, Simona; SUMMA, Vincenzo; (143 pag.)WO2018/115275; (2018); A1;,
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