Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 62451-84-7, name is Methyl 2-(3-(trifluoromethyl)phenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows., name: Methyl 2-(3-(trifluoromethyl)phenyl)acetate
To a stirred solution of methyl 2-[3-(trifluoromethyl)phenyl]acetate (6.33 g, 29 mmol) in DMF (45 mL) at 0C was added NaH (60%, 1.28 g, 31.9 mmol). The reaction mixture was stirred for 1 hour and then canuulated drop wise into a solution of 2-(4-bromobutoxy)tetrahydropyran (6.88 g, 29 mmol) in DMF (45 mL) also at 0C. The reaction was further stirred at RT for one hour and poured onto an aqueous saturated solution of NH4C1. The product was extracted with EtOAc, and the combined organic phase was dried over Na2S04 and concentrated under vacuo. A column chromatography (Si02, Heptane / EtOAc) gave 7.82 g (72%) of methyl 6-tetrahydropyran-2- yloxy-2-[3-(trifluoromethyl)phenyl]hexanoate as a light yellow oil.
According to the analysis of related databases, 62451-84-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BARTELS, Bjoern; JAKOB-ROETNE, Roland; LIMBERG, Anja; NEIDHART, Werner; RATNI, Hasane; REUTLINGER, Michael; SARIE, Jerome Charles; VASTAKAITE, Greta; (61 pag.)WO2018/83050; (2018); A1;,
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