Reference of 2216-92-4, A common heterocyclic compound, 2216-92-4, name is N-Phenylglycine Ethyl Ester, molecular formula is C10H13NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Prepared in the manner of Example 16 except 4- (trifluoromethyl) benzyl bromide was substituted for 4-chlorobenyl chloride. Purification by flash chromatography (10: 1 to 5: 1 hexanes/EtOAc) afforded the title compound as a yellow oil (30%). 1H NMR [(CDCI3)] [8] 7.62 (d, 2H), 7.52 (d, 2H), 7.43 (d, 2H), 6.68 (d, 2H), 4.73 (s, 2H), 4.25 (q, 2H), 4.14 (s, 2H), 1.30 (t, 3H). Anal. Calc. [FOR C21H18NO3FS] : C, 50.11 ; H, 3.60 ; N, 2.78. Found: C, 50.01 ; H, 3.98 ; N, 2.61. HRMS (MH+). Calc. : 504.1221. Found: 504.1227.
The synthetic route of 2216-92-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics