In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40872-87-5, name is Methyl 3-amino-4-chlorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C8H8ClNO2
To an ice-cold aqueous solution of concentrated hydrochloric acid (30 mL) was added compound 2 (7.4 g, 40 mmol), followed by the dropwise addition of sodium nitrite (3.036 g, 44.0 mmol) in distilled water (5 mL). After 0.5 h of stirring at 0 C, tin(II) chloride (18.05 g, 80 mmol) in concentrated hydrochloric acid (30 mL) was added dropwise to the above solution. The reaction was stirred for 4 h at 0 C and filtered and successively washed with concentrated hydrochloric acid (15 mL). The precipitate was dissolved in distilled water and filtered. When the filtrate was adjusted to pH 13 by adding 4 mol/L sodium hydroxide under stirring, a large amount of solid formed and was filtered and dried to obtain compound 3. White solid, yield: 63.9%, m.p.132-133 C. 1H NMR (400 MHz, CDCl3) delta 7.76 (s, 1H, Ph-H), 7.40 (d, J = 8.2 Hz, 1H, Ph-H), 7.35 – 7.23 (m, 1H, Ph-H), 5.81 (s, 1H, NH), 3.91 (s, 3H, OCH3), 3.67 (s, 2H, NH2).
The synthetic route of 40872-87-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Li, Feng-Yun; Wang, Yuan-Hong; Liu, Jing-Bo; Li, Yu-Xin; Li, Zheng-Ming; Bioorganic and Medicinal Chemistry; vol. 27; 5; (2019); p. 769 – 776;,
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