In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 23786-14-3, name is Methyl 4-methoxyphenylacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C10H12O3
NBS (9.06 g, 50.90 mmol) and AIBN (398 mg, 2.43 mmol) was added into a solution 2-(4-methoxyphenyl)acetate17(8.74 g, 48.50 mmol) in carbon tetrachloride (50 ml). The reaction was refluxed at 80Cfor 4h and quenched with water. Carbon tetrachloride was removed under vacuum. The reaction was extracted with ethyl acetate. The organic phase was washed with sodium thiosulfate (1M) and then saturated sodium chloride, dried over anhydrous sodium sulfate and concentrated to obtain the crude product18(12.43 g, 99% yield) as a white solid.1H NMR (400 MHz, CDCl3) delta 7.52-7.45 (m, 2H), 6.91-6.85 (m, 2H), 5.35 (s, 1H), 3.81 (s, 3H), 3.79 (s, 3H).
The synthetic route of 23786-14-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Li, Guangzhe; Dong, Huijuan; Ma, Yao; Shao, Kun; Li, Yueqing; Wu, Xiaodan; Wang, Shisheng; Shao; Zhao, Weijie; Bioorganic and Medicinal Chemistry Letters; vol. 29; 16; (2019); p. 2327 – 2331;,
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