Reference of 87-24-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 87-24-1 name is Ethyl 2-methylbenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Compound 1-1 (1.97g, 12mmol, 1eq), NBS (2.35g, 13.2mmol, 1eq), AIBN (98.4mg, 0.6mmol, 0.05 eq) was dissolved in 20mL of acetonitrile, the reaction was heated at reflux overnight, with TCL plate detection reaction, after completion of the reaction, the solvent under reduced pressure to give the crude product spin dry, and separated by a silica gel column, particle size of 200-300 mesh silica gel, eluent ratio of methylene chloride / petroleum ether = 1: 1, yields 56%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 2-methylbenzoate, and friends who are interested can also refer to it.
Reference:
Patent; University of Jinan; Lin, Weiying; Ren, Mingguang; Deng, Beibei; (14 pag.)CN105884713; (2016); A;,
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