Adding a certain compound to certain chemical reactions, such as: 84228-44-4, name is Methyl 4-amino-3-chlorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84228-44-4, Application In Synthesis of Methyl 4-amino-3-chlorobenzoate
Step 1: methyl 4-amino-3-chlorobenzoate (1.24g, 6.68 mmol) was dissolved in THF (20 ml) followed with Boc anhydride (20.4 ml, 1M in THF) and DMAP (0.1 eq). The mixture was refluxed for 1h15, then it was allowed to reach the room temperature before to evaporate it to dryness.Step 2: The obtained crude was dissolved in MeOH (40 ml), K2CO3 (2.3 g) was added and the mixture was refluxed for 2 h. The mixture was allowed to reach the room temperature, it was then diluted with ether (100 ml) and washed with Brine (3*30 ml), followed with citric acid 0.5 M (10 ml). The organic layer was dried with MgSO4, filtered off and purified on silica gel Biotage column to get the desired compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-amino-3-chlorobenzoate, and friends who are interested can also refer to it.
Reference:
Patent; Genesis Technologies Limited; AHLFORS, Jan-Eric; MEKOUAR, Khalid; (105 pag.)EP2697246; (2018); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics