Electric Literature of 110-42-9,Some common heterocyclic compound, 110-42-9, name is Methyl decanoate, molecular formula is C11H22O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
10154] The experimental apparatus consists of a classic glass, double jacketed chemical engineering reactor with a volume of 1 litre with an effective mixing system. This is topped with a separating column fitted with a variable-reflux condenser. It also has a recirculating loop fitted with a gear- type pump and a 600 W microwave generatot10155] Add 530 mL xylenes, 111.58 g thsed methyl decanoate and 34.00 g powdered sodium methoxide. Once the reagents have been added, render the reactor inert with a continuous flow of nitrogen gas. Recirculate the mixture through the external circuit at a rate of 15 kg/h. Bring to boiling and total reflux, and then switch the microwave sourceon.10156] Add 68.45 g acetophenone over one hout Once it has all been added, let the reaction continue for another 15 minutes. Throughout all this time, draw the methanol off the reaction mixture. After the 15 minutes of finishing time, switch off the microwave source and the heatet AcidiFy the mixture and then wash it.10157] Analysis of the organic phase by gas phase chromatography shows that almost all the acetophenone is consumed and that the DeBM titre is 98.3%.10158] DeBM productivity during the reaction phase is129.3 kg/hIm3.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl decanoate, its application will become more common.
Reference:
Patent; DEXERA; Honnart, Stephane; Galy-Jammou, Philippe; US2014/88325; (2014); A1;,
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