Synthetic Route of 99548-54-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99548-54-6, name is Methyl 3-bromo-2-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 106A Methyl 6-amino-3-bromo-2-methylbenzoate A -20 C. solution of methyl 3-bromo-2-methylbenzoate (10 g, 43.7 mmol) in concentrated H2SO4 (100 mL) was treated dropwise with a solution of concentrated HNO3 (2.75 muL) in concentrated H2SO4 (50 mL) at a rate that maintained the temperature below -15 C. The reaction was then stirred at 0 C. for 30 minutes, poured into ice, and extracted with diethyl ether. The extract was washed with aqueous NaHCO3 and brine, dried (Na2SO4), filtered, and concentrated to give 9.32 g of the nitrated product. The crude product was added to a solution of SnCl2 (32.2 g, 170 mmol) in concentrated HCl (34 mL) and methanol (52 mL) and the resulting suspension was stirred at room temperature for 4 hours. The resulting solution was concentrated, adjusted to pH 7 with aqueous NaOH, and filtered through diatomaceous earth (Celite). The pad was washed with diethyl ether and dichloromethane and the combined filtrates were concentrated. The concentrate was purified by silica gel chromatography with 10-20% ethyl acetate/hexanes to give 3.59 g of the desired product. MS (ESI(-)) m/e 243 (M-H)-.
The synthetic route of Methyl 3-bromo-2-methylbenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Curtin, Michael L.; Davidsen, Steven K.; Frey, Robin R.; Heyman, Howard R.; Holms, James H.; Michaelides, Michael; Steinman, Douglas H.; US2005/26976; (2005); A1;,
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