Reference of 57381-62-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57381-62-1, name is Methyl 2-bromo-4-chlorobenzoate, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of methyl 2-bromo-4-chlorobenzoate (In-27, 5.0 g, 20.0 mmol) in MeOH (50 mL) was added N2H4.H20 (80percent, 50 mL). The resulting solution was heated at 60 ¡ãC for 1 h, until TLC show SM consumed. After concentration, the resulting solid was dissolved in EA (100 mL), washed with brine (2 x 30 mL), dried over Na2504 and concentrated to dryness to afford desired product 2-bromo-4-chlorobenzohydrazide Sc (2.8 g, 56percent). ?H NMR(300 MHz, DMSO-d6): oe 9.58 (s, 1H), 7.80 (d, J=1.8 Hz, 1H), 7.52 (dd, J8.1 Hz, J=2.1 Hz, 1H), 7.38 (d,J=8.1 Hz, 1H), 4.49 (s, 2H). LC-MS [M+Hj 251;
The chemical industry reduces the impact on the environment during synthesis Methyl 2-bromo-4-chlorobenzoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI; HAJJAR, Roger; DEVITA, Robert; (68 pag.)WO2019/18718; (2019); A1;,
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