Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 176694-36-3, name is Methyl 4-fluoro-3-(trifluoromethyl)benzoate, A new synthetic method of this compound is introduced below., COA of Formula: C9H6F4O2
To a stirred solution of 4,48 g (22.5 mmol) 4-Fluoro-3-trifluoromethyl-benzoic acid methyl ester (Rarechem) and 60.0 ml dimethylsulphoxid are added 2.23 g (27.0 mmol) dimethylamine hydrochloride and 6.54 g (47.3 mmol) potassium carbonate. The reaction mixture is stirred for 8h at 60C in an autoclave and is reduced with high vacuum rotation evaporator at 65C. The residue is diluted with dichloromethane, washed twice with water. The combined water phases are extracted with dichloromethane. The combined dichloromethane phases are washed with diluted sodium hydrogen carbonate solution, dried with sodium sulphate and concentrated. The oily crude is purified by column chromatography and the desired product 2.3.2.a is obtained in 72 % yield (4,00 g, 16,2 mmol). MS-ESI: 248 (M+ +1, 100). Elementary analysis: C 53.44% H 4.89% F 23.05% N 5.67% Determined: C 53.48% H 4.90% F 23.03% N 5.65%
The synthetic route of 176694-36-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bayer Schering Pharma Aktiengesellschaft; EP1916003; (2008); A1;,
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