Application of 57381-62-1, The chemical industry reduces the impact on the environment during synthesis 57381-62-1, name is Methyl 2-bromo-4-chlorobenzoate, I believe this compound will play a more active role in future production and life.
(4-Dibenzofuranyl) boronic acid ((4-dibenzofuranyl) boronic acid), 30 g (141.5 mmol), methyl-2-bromo-4-chlorobenzoate (methyl-2-bromo-5-chlorobenzoate), 37.1 g ( 148.6 mmol), tetrakistriphenylphosphine palladium 8.2 g (7.1 mmol) dissolved in toluene 550 ml was added to flask placed in a nitrogen atmosphere. Potassium carbonate (potassium carbonate) 104.2 g (707.51 mmol) was dissolved in 550 ml toluene, and the aqueous solution 353.8 ml was stirred under reflux for 12 hours. After completion of the reaction, the mixture was extracted with ethyl acetate, dried with magnesium sulfite (magnesium sulphate), filtered and the filtrate was concentrated under reduced pressure. The resulting mixture was purified by silica gel column chromatography using n-hexane / dichloromethane (7:3 volume ratio) to give the desired compound of intermediate (D) 38.2 g (80percent yield) as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromo-4-chlorobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CHEIL INDUSTRIES INC.; JO, YOUNG KYOUNG; KANG, EUI SU; KIM, DONG YEONG; LUI, JIN HYUN; MIN, SOO HYUN; YANG, YONG TAK; OH, JAE JIN; YU, EUN SUN; LEE, HAN ILL; JUNG, HO KUK; (42 pag.)KR2015/45809; (2015); A;,
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