Some common heterocyclic compound, 2178-24-7, name is Ethyl (2-bromophenyl)acetate, molecular formula is C10H11BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 2178-24-7
D. o-Bromophenethyl alcohol To a stirred suspension of 106.0 g of lithium aluminum hydride in 3.7 l of anhydrous ether, is added, dropwise, a solution of 780.0 g of ethyl o-bromophenylacetate in 3.1 l of anhydrous ether. The reaction mixture is stirred for about three hours and then heated under reflux for about five hours. The mixture is cooled, then treated dropwise with 800 ml of water, and 1.5 l of 10% aqueous hydrochloric acid. The ether solution is washed, dried, concentrated, and the residue is distilled to give 554.0 g of o-bromophenethyl alcohol, bp. about 130-132 (8mm), nD20 1,5760.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2178-24-7, its application will become more common.
Reference:
Patent; E. R. Squibb & Sons, Inc.; US3957787; (1976); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics