Electric Literature of 5026-62-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5026-62-0, name is Sodium 4-(methoxycarbonyl)phenolate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
The above titled compound was prepared by the Method E (ArXBC(R10R11): (4-carboxyphenoxy)methyl). R. Compound A (100 mg) was placed in a 8.0 mL, polypropylene filter column fitted with a 2-way polypropylene stopcock. The resin was pretreated with CH2Cl2 (2 x 3 mL). The swollen resin was then deprotected with 50% TFA/CH2Cl2 (3mL, 30min). The resin was rinsed in the following order: CH2Cl2 (2 x 3 mL), CH3OH (2 x 3 mL), CH2Cl2 (2 x 3 mL). Bromoacetic acid (85 mg) and diisopropyl-carbodiimide (80 mg) in DMF (2.0 mL) was added and the mixture was stirred for 1 hr at room temperature. The resin was filtered and washed in the following order: DMF (2 x 3 mL), CH2Cl2 (2 x 3 mL), DMF (2 x 3 mL), respectively. If a Kaiser test on a small quantity of the resin is positive (blue) then ‘repeat the’ coupling procedure until a negative result is obtained. Methyl p-hydroxybenzoate (91 mg) was pretreated with NaH (20 mg) in THF (0.5 mL) and DMF (2 mL) for 1.5 hr. The resulting phenoxide was added to the resin and the mixture was stirred for 2 hr at room temperature. The resin was then filtered and washed in the following order: DMF (2 x 3 mL), CH2Cl2 (2 x 3 mL), THF (2 x 3 mL), respectively. The resulting resin was then dried in vacuum to constant weight. The cleavage of the resin (saponification) was achieved with LiOH/CH3OH/THF (1:6:20). The resin bound material was placed in the polypropylene column and pretreated with THF (3 mL). Then THF (4 mL), CH3OH (1.0 mL) and 2N LiOH (0.390 mL) were added. The mixture was stirred for 15 min and filtered to a clean and pre weighed test tube. The resin was next washed with THF/5% CH3OH (2mL) and the combined filtrates were evaporated. The resulting gum was dissolved in H2O (1 mL). The solution was then acidified with 1N HCl to pH 2.0. The precipitate was centrifuged, washed with water (2 x 5 mL) and dried in vacuum to furnish the compound of Example 12: ESMS (m/z) 529 (M-H)-
The synthetic route of Sodium 4-(methoxycarbonyl)phenolate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TANABE SEIYAKU CO., LTD.; EP1144365; (2004); B1;,
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