Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 46193-76-4, name is Ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate, A new synthetic method of this compound is introduced below., Quality Control of Ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate
Ethyl-6-nitro-4H-thieno[3,2-b]pyrrole-5-carboxyIate (95). Pulverized Cu(NO3)2′ hydrate (953 mg, 4.10 mmol) dissolved in acetic anhydride (8.2 niL) was added dropwise to a solution of carboxylate 96 dissolved in acetic anhydride (10 mL) at 0 0C. The addition was completed in 1.5 h and the mixture was then stirred at r.t. for 2 h. After filtration the organic layer was poured over ice and extracted with diethyl ether (3×30 mL). The combined organic layers were washed with saturated aqueous sodium carbonate solution and dried over MgSO4. After the removal of organic solvent, the residue was purified by column chromatography (EtOAc/Hexane: 1/6) to give the desired nitration product 94 (148 mg, 12 %) as a light yellow solid along with another nitration product 95 (300 mg, 25%).
The synthetic route of 46193-76-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; THOMAS, Craig J.; AULD, Douglas S.; INGLESE, James; SKOUMBOURDIS, Amanda P.; JIANG, Jian-Kang; BOXER, Matthew; WO2010/42867; (2010); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics