Some common heterocyclic compound, 2318-25-4, name is Ethyl 3-ethoxy-3-iminopropionate hydrochloride, molecular formula is C7H14ClNO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Ethyl 3-ethoxy-3-iminopropionate hydrochloride
The imidate salt 1g2 (1.5 g, 7.65 mmol) was combined with 2-methyl-3-aminoanisole 1ml (1.05 g, 7.65 mmol, 1 eq.) in ethanol (15 mL) under an N2 atmosphere. The reaction mixture was stirred at RT (24 h) and monitored by HPLC. The reaction mixture was concentrated and then ether was added and the mixture filtered. The solids were washed with ether and the combined ether washes concentrated in vacuo. The resulting adduct 1m2 was purified by chromatography (SiO2, 15percent EtOAc/hexanes) to obtain as a yellow oil (2.11 g, 99percent). MS electrospray: (M+H)+; 280 and (M-H)-; 278.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2318-25-4, its application will become more common.
Reference:
Patent; Boehringer Ingelheim International GmbH; US2006/19905; (2006); A1;,
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