Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1150566-27-0, name is Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H8ClN3O2
[0328] Step 3: To a solution of B7-3 (600 mg, 2.0 mmol) and {2-[4-fluoro-2-(1-hydroxy-ethyl)- phenoxy]-ethyl}-carbamic acid tert-butyl ester (450 mg, 2.0 mmol) in dry THF (40.0 mL) at -78C was added NaH (60%, 80 mg, 2.0 mmol) in portion. The suspension was stirred at -78 C for 4 h and allowed to warm to 0 C and stirred for additional 4 h. The mixture was then put in the freezer at -20 C overnight. LC-MS showed a good conversion to the desired product. The mixture was then quenched with a mixture of ice and iN HC1 and extracted with EtOAc (3 x 20 mL). The organic layer was dried over Na2504, concentrated and purified twice to afford the desired product B7 as a yellow solid (240 mg, 25%):
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; TP THERAPEUTICS, INC.; CUI, Jingrong Jean; LI, Yishan; ROGERS, Evan W.; ZHAI, Dayong; WO2015/112806; (2015); A3;,
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