In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 107947-17-1, name is Methyl 3-bromo-4-chlorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of Methyl 3-bromo-4-chlorobenzoate
The compound methyl 4-chloro-3-bromobenzoate 19b (1.2 g, 4.8 mmol), trimethyl Silyl acetylene (0.95 g, 9.7 mmol), palladium acetate (108 mg, 0.48 mmol), triphenylphosphine (254 mg, 0.97 mmol), cuprous iodide (185 mg, 0.97 mmol) and triethylamine (25 mL) Mix in a tube and heat and stir at 100 C for 15 hours.After the reaction was completed, the solution was desolvated under reduced pressure, and the residue was purified by column chromatography silica gel chromatography (petroleum ether / ethyl acetate = 10/1) to obtain the target product 4-chloro-3-((trimethylsilyl) ethynyl). Methyl benzoate 19c (1 g, yellow solid), yield: 78%.
The synthetic route of 107947-17-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BEIJING TIANCHENG PHARMA CO., LTD.; CHEN, XIANGYANG; GAO, YINGXIANG; KONG, NORMAN XIANGLONG; (118 pag.)TW2019/38538; (2019); A;,
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