Application of 4606-07-9,Some common heterocyclic compound, 4606-07-9, name is Ethyl cyclopropanecarboxylate, molecular formula is C6H10O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 10 3-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-6-methoxy-5-morpholino-imidazo[1,5-a]quinazoline (Compound 70) A mixture of 6-methoxy-5-morpholino-imidazo[1,5-a]quinazoline-3-carboxamide oxime (0.9 g), ethyl cyclopropylcarboxylate (1.7 g), molecular sieves (3 g), and 80% sodium hydride (0.1 g) in 20 ml of dry DMF was heated for 11/2 hours at 120 C. The mixture was cooled to room temperature, diluted with acetic acid (0.5 ml) and methylene chloride (20 ml) and filtered. The filtered mixture was evaporated and the residue was purified by column chromatography (HPLC) (eluent: methylene chloride:acetone (2:1)) to give yellow crystals of the title compound, m.p. 227-228 C. Yield 0.38 g. In the same manner the following compound was prepared:
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl cyclopropanecarboxylate, its application will become more common.
Reference:
Patent; Novo Nordisk A/S; US5371080; (1994); A;,
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