Synthetic Route of 39622-80-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39622-80-5, name is Dimethyl 2-bromoisophthalate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a suspension of 4 (1.37g, 5.01 mmol) and Me4NF (1.86 g, 20.0 mmol) in DME (20mL) was added Me3SiCF3 (3.00 mL, 20.3 mmol) at 40 C. The reaction mixture wasstirred for 4 hours at the same temperature and then Me3SiCF3 (1.45 mL, 9.81 mmol)was added. After the mixture was stirred for 17 h at 40 C and then for an hour at roomtemperature, 10% HCl aq. was added at 0 C. The mixture was extracted with Et2O. Thecombined organic layer was washed with water and brine and then dried over MgSO4.After the solvents were removed in vacuo, the crude product was purified by silica gelcolumn chromatography eluted by Et2O/n-hexane = 1:2 to give 5 (1.60 g, 3.27 mmol) aspale yellow solid in 65% yield. The single crystals suitable for X-ray analysis wereobtained by recrystallization from CH2Cl2/n-hexane.
The synthetic route of Dimethyl 2-bromoisophthalate has been constantly updated, and we look forward to future research findings.
Reference:
Article; Imada, Yasuyuki; Kukita, Tomomi; Nakano, Hideyuki; Yamamoto, Yohsuke; Bulletin of the Chemical Society of Japan; vol. 89; 5; (2016); p. 546 – 548;,
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