Synthetic Route of 35613-44-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35613-44-6, name is Methyl 2-(2-aminophenyl)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
2-bromo-1-(3,4-dihydroisoquinolin-2(1H)-yl)ethanone (370 mg, 1.45 mmol), methyl 2-(2-aminophenyl)acetate (200 mg, 1.21) Methyl, anhydrous potassium carbonate (500 mg, 3.63 mmol) was added to acetonitrile (10 mL) successively, and the mixture was stirred and warmed at 80 C for 5 hours.. The TLC monitors the end of the reaction. The reaction mixture was cooled to room temperature, and the mixture was evaporated to dryness. Purification by crude silica gel column chromatography (petrole ether / ethyl acetate = 4 / 1) afforded 2-(2-((2-(3,4-dihydroisoquinolin-2(1Eta)yl)-2-oxoethyl)amino)phenyl)methyl acetate(N-001) was obtained as a pale yellow oil (150 mg, 31%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-(2-aminophenyl)acetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shaoxing Cong Ling Pharmaceutical Technology Co., Ltd.; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Yang Huaiyu; (51 pag.)CN109020887; (2018); A;,
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