Synthetic Route of 148547-19-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 148547-19-7 as follows.
BINAP (0.67 g; 1.1 mmol; 0.05 eq.) and palladium acetate (0.24 g; 1.1 mmol; 0.05 eq.) were added to a suspension methyl 4-bromo-3-methylbenzoate (5 g; 21.8 mmol; 1 eq.), CS2CO3 (10.65 g; 32.7 mmol; 1 .5 eq.) and piperidine (2.2 g; 26 mmol; 1.2 eq.) in dioxane (100 mL) and the reaction mixture was refluxed for 15 hours. After filtration through a pad of Celite, the solution was concentrated in vacuo and the residue purified by column chromatography (petroleum ether/ethyl acetate, 80/20) to afford the title compound (4.9 g, 96%) as a brown solid.LC/MS : 233.9 (M+H)+. 1H NMR (CDCI3, 400 MHz) delta 7.84-7.82 (m, 2H), 6.99-6.97 (m, 1 H), 3.92 (s, 3H), 2.93-2.90 (m, 4H),1.76-1.67 (m, 4H, m), 1.63-1.62 (m, 2H).
According to the analysis of related databases, 148547-19-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SERONO S.A.; WO2009/43890; (2009); A1;,
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